Redundant Mechanisms for Stable Cell Locomotion Revealed by Minimal Models

Redundant mechanisms for stable cell locomotion revealed by minimal models.

Crawling of eukaryotic cells on flat surfaces is underlain by the protrusion of the actin network, the contractile activity of myosin II motors, and graded adhesion to the substrate regulated by complex biochemical networks. Some crawling cells, such as fish keratocytes, maintain a roughly constant shape and velocity. Here we use moving-boundary simulations to explore four different minimal mec...

Fuzzy Reliability Optimization Models for Redundant Systems

In this paper, a special class of redundancy optimization problem with fuzzy random variables is presented. In this model, fuzzy random lifetimes are considered as basic parameters and the Er-expected of system lifetime is used as a major type of system performance. Then a redundancy optimization problem is formulated as a binary integer programming model. Furthermore, illustrative numerical ex...

Mechanisms of cyclic AMP compartmentation revealed by computational models

Computing Minimal Models, Stable Models, and Answer Sets

We propose and study algorithms to compute minimal models, stable models and answer sets of t-CNF theories, and normal and disjunctive t-programs. We are especially interested in algorithms with non-trivial worst-case performance bounds. The bulk of the paper is concerned with the classes of 2and 3-CNF theories, and normal and disjunctive 2and 3-programs, for which we obtain significantly stron...

Hearing loss: mechanisms revealed by genetics and cell biology.

Hearing loss (HL), or deafness in its most severe form, affects an estimated 28 and 22.5 million Americans and Europeans, respectively. The numbers are higher in regions such as India and the Middle East, where consanguinity contributes to larger numbers of recessively inherited hearing impairment (HI). As a result of work-related difficulties, educational and developmental delays, and social s...